The position of some necessary antioxidants in main scientific outcomes of topics with COVID-19

In a current overview revealed in Meals Science and Diet, researchers investigated the position of antioxidants similar to selenium, zinc, α-lipoic acid, and nutritional vitamins A, E, D, and C in enhancing the scientific outcomes of coronavirus illness 2019 (COVID-19).

The position of some necessary antioxidants in main scientific outcomes of topics with COVID-19
Research: Antioxidants and scientific outcomes of sufferers with coronavirus illness 2019: A scientific overview of observational and interventional research. Picture Credit score: Panchenko Vladimir/Shutterstock


Latest analysis on COVID-19 has indicated that oxidative stress could possibly be one of many important causes behind the pathogenicity of extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Comorbidities similar to cardiovascular ailments and diabetes mellitus improve the danger of extreme COVID-19 as a result of these situations elevate oxidative stress ranges within the physique. The binding of the SARS-CoV-2 spike protein with the angiotensin-converting enzyme 2 receptor is believed to disrupt the renin-angiotensin system and improve oxidative stress.

Oxidative stress is assumed to weaken the immune system and trigger irritation and cell dying. Contemplating the intensive involvement of oxidative stress in COVID-19 scientific outcomes, antioxidants, which restore oxidative harm to mobile parts, might present potential therapeutic avenues to handle the severity of the illness.

Concerning the examine

Within the current overview, the researchers centered on six non-enzymatic antioxidants, which included two minerals (selenium and zinc), 4 nutritional vitamins (A, D, E, and C), and one quasi-vitamin (α-lipoic acid). They chose observational and interventional research that included COVID-19 sufferers and excluded research on animal fashions and ex vivo or in vitro experiments.

Observational research had been chosen based mostly on an in depth inclusion criterion, which included elements like sturdy examine design, outcomes of curiosity similar to hospitalization and inflammatory biomarkers, publicity of curiosity consisting of various ranges of the antioxidants in dietary supplements or meals, and outcomes being reported when it comes to odds ratio, hazard ratio, β coefficient, and relative danger.

Interventional research had been chosen for together with randomized managed, pre- or post-, and quasi-experimental trials; and for investigating the impact of antioxidant infusions or dietary supplements on the scientific outcomes of COVID-19.

Research with descriptive observational knowledge, imprecise estimates, and research that administered the antioxidants of curiosity with different vitamins, in addition to non-peer-reviewed publications, commentaries, editorials, and case studies, had been excluded.


The findings of the overview recommend that nutritional vitamins C and D and minerals zinc and selenium could possibly be extremely helpful in enhancing lots of the scientific outcomes of COVID-19 and reducing the severity of the illness. Vitamin C supplementation was seen to scale back inflammatory biomarker ranges and mortality and improve the Horowitz index, which is used to evaluate the lung perform of sufferers on ventilators.

Observational research reported that inadequate vitamin D was linked to extreme COVID-9 manifestations similar to hypoxia, fever, and lymphocytopenia. Supplementation with vitamin D lowered air flow and intensive care unit (ICU) admission necessities. Research additionally discovered vitamin D ranges to be inversely related to the degrees of inflammatory biomarkers similar to C-reactive protein (CRP), ferritin, D-dimer, and neutrophil and lymphocyte concentrations. 

The overview additionally mentioned the helpful results of mineral antioxidants. Observational research indicated that selenium might play a task in lowering mortality charges in COVID-19 circumstances. Serum zinc ranges had been inversely associated to the severity of COVID-19 signs.

Research confirmed that oral zinc sulfate dietary supplements considerably lowered the necessity for air flow, hospitalization, and ICU admission. Inflammatory and an infection biomarkers similar to CRP, interleukins, erythrocyte sedimentation charge, and procalcitonin had been inversely proportional to serum zinc ranges.

For the antioxidants α-lipoic acid, and nutritional vitamins A and E, no observational or interventional research had been accessible. Nevertheless, the authors mentioned the significance of vitamin A in enhancing the immune system by selling the manufacturing of immunoglobulins, sustaining the epithelia and mucin layers of the respiratory tracts, and regulating the genes concerned in inflammatory responses.

Equally, vitamin E is believed to play a task in defending cells from reactive oxidative species, T cell perform, and the manufacturing of antibodies. The involvement of α-lipoic acid in lowering oxidative stress and inhibiting the activation of inflammatory transcription elements was additionally talked about within the overview.


Total, the findings of the overview point out that antioxidants similar to nutritional vitamins C and D and minerals similar to selenium and zinc are potential avenues for ameliorating lots of the extreme manifestations of COVID-19. Nonetheless, extra research are required to type conclusions. Regardless of the absence of observational or interventional research on the roles of nutritional vitamins A and E and α-lipoic acid, the organic roles these antioxidants play within the physique point out their potential as therapeutic brokers towards COVID-19.

Journal reference:

  • Foshati, S., Mirjalili, F., Rezazadegan, M., Fakoorziba, F., & Amani, R. (2022). Antioxidants and scientific outcomes of sufferers with coronavirus illness 2019: A scientific overview of observational and interventional research. Meals Science & Diet, 00, 1– 14. doi:

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